Ankylosing spondylitis (ankylosing spondylitis): Definition
As ankylosing spondylitis or ankylosing spondylitis (Or ankylosing spondylitis) refers to a chronic, inflammatory rheumatic disease, to the Autoimmune diseases belongs: Here, the immune system mistakenly directed against the body's own tissue, creating a permanent inflammation occurs.
Although ankylosing spondylitis can also the joints of the arms and legs, the sinews and tendons, the iris of the eyes and - more rarely - affect internal organs. Above all, the ankylosing spondylitis but the spinal column durable inflamed and can increasingly stiffen.
For this reason it is called the ankylosing spondylitis and ankylosing spondylitis.
Although a ankylosing spondylitis rheumatic Disease, are among those affected in the blood no rheumatoid factor determine - they are seronegative. This feature also applies to other rheumatic diseases to which the ankylosing spondylitis several symptoms in common have - such as chronic inflammatory back pain and / or arthritis of the joints of the limbs. Therefore, it summarizes these diseases in a group called seronegative spondyloarthropathies or Spondylarthritiden together.
Each seronegative spondyloarthropathies or ankylosing spondylitis is characterized in that in those affected frequently a particular inherited trait - HLA-B27 - present (hence they are referred to as HLA-B27-associated spondyloarthropathies). Group of seronegative spondyloarthropathies next ankylosing spondylitis include: