Cushing’s Syndrome: Endogenous Cushing’s Syndrome
Rarely has Cushing's syndrome Inside possible causes. Such endogenous Cushing's syndrome occurs when the body without external influences makes too much cortisol. This can be done both ACTH-dependent and ACTH-independent.
Creates an endogenous Cushing's syndrome ACTH-dependent, this means that the body releases too many glucocorticoids because it forms the hormone ACTH in excessive amounts. The most common causes of ACTH-dependent Cushing's syndrome are benign growths (called. adenomasSOG) or malignant tumors (. carcinomas) Which the formation of ACTH stimulate:
an endogenous Cushing's syndrome developed ACTH-independent, the Glukokortikoidspiegel is increased, although the ACTH level is normal. The reasons for such an ACTH-independent Cushing's syndrome are the adrenal itself (i.e. adrenal).
For an endogenous ACTH-independent Cushing's syndrome come as causes Adenomas or carcinomas of the adrenal cortex (So-called. Neoplasms) in question that trigger an increased Kortisolbildung. Thereby partially play hereditary factors a role: More than a third of adrenal adenomas, which lead to hypercortisolism, changes in a gene can be detected that have an unbridled cortisol result. In rare cases, even benign tissue growth (So-called. Hyperplasia) responsible for the disease.